Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA135363 | ENA |

REPOSITORIES: ENA

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Publications

Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing.

Arlt Martin F MF   Ozdemir Alev Cagla AC   Birkeland Shanda R SR   Lyons Robert H RH   Glover Thomas W TW   Wilson Thomas E TE  

Genetics 20110106 3


Copy-number variants (CNVs) are a major source of genetic variation in human health and disease. Previous studies have implicated replication stress as a causative factor in CNV formation. However, existing data are technically limited in the quality of comparisons that can be made between human CNVs and experimentally induced variants. Here, we used two high-resolution strategies-single nucleotide polymorphism (SNP) arrays and mate-pair sequencing-to compare CNVs that occur constitutionally to  ...[more]

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