Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Epidermal differentiation: basal vs. suprabasal keratinocytes

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA135569 | ENA |

REPOSITORIES: ENA

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Publications

Transcriptional profiling of epidermal differentiation.

Radoja Nada N   Gazel Alix A   Banno Tomohiro T   Yano Shoichiro S   Blumenberg Miroslav M  

Physiological genomics 20060705 1


In epidermal differentiation basal keratinocytes detach from the basement membrane, stop proliferating, and express a new set of structural proteins and enzymes, which results in an impermeable protein/lipid barrier that protects us. To define the transcriptional changes essential for this process, we purified large quantities of basal and suprabasal cells from human epidermis, using the expression of beta4 integrin as the discriminating factor. The expected expression differences in cytoskeleta  ...[more]

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