Dataset Information


Homo sapiens

ABSTRACT: Global gene expression analysis of six cadmium-transformed UROtsa cell isolates

ORGANISM(S): Homo sapiens  



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Variation of keratin 7 expression and other phenotypic characteristics of independent isolates of cadmium transformed human urothelial cells (UROtsa).

Somji Seema S   Zhou Xu Dong XD   Mehus Aaron A   Sens Mary Ann MA   Garrett Scott H SH   Lutz Krista L KL   Dunlevy Jane R JR   Zheng Yun Y   Sens Donald A DA  

Chemical research in toxicology 20100201 2

This laboratory has shown that a human urothelial cell line (UROtsa) transformed by cadmium (Cd(2+)) produced subcutaneous tumor heterotransplants that resemble human transitional cell carcinoma (TCC). In the present study, additional Cd(2+) transformed cell lines were isolated to determine if independent exposures of the cell line to Cd(2+) would result in malignantly transformed cell lines possessing similar phenotypic properties. Seven independent isolates were isolated and assessed for their  ...[more]

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