Genomics

Dataset Information

59

Mus musculus


ABSTRACT: MicroRNA expression profiling of quiescent and activated muscle stem cells

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA136277 | ENA |

REPOSITORIES: ENA

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Publications


Among the key properties that distinguish adult mammalian stem cells from their more differentiated progeny is the ability of stem cells to remain in a quiescent state for prolonged periods of time. However, the molecular pathways for the maintenance of stem-cell quiescence remain elusive. Here we use adult mouse muscle stem cells (satellite cells) as a model system and show that the microRNA (miRNA) pathway is essential for the maintenance of the quiescent state. Satellite cells that lack a fun  ...[more]

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