Dataset Information


Homo sapiens

ABSTRACT: Genome-wide analysis of cellular SMD or NMD substrates that regulated by Upf1 or PNRC2 in HeLa cell

ORGANISM(S): Homo sapiens  



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Staufen1-mediated mRNA decay functions in adipogenesis.

Cho Hana H   Kim Kyoung Mi KM   Han Sisu S   Choe Junho J   Park Seung Gu SG   Choi Sun Shim SS   Kim Yoon Ki YK  

Molecular cell 20120412 4

The double-stranded RNA binding protein Staufen1 (Stau1) is involved in diverse gene expression pathways. For Stau1-mediated mRNA decay (SMD) in mammals, Stau1 binds to the 3' untranslated region of target mRNA and recruits Upf1 to elicit rapid mRNA degradation. However, the events downstream of Upf1 recruitment and the biological importance of SMD remain unclear. Here we show that SMD involves PNRC2, decapping activity, and 5'-to-3' exonucleolytic activity. In particular, Upf1 serves as an adap  ...[more]

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