Dataset Information


Homo sapiens

ABSTRACT: Identification of STAT5 target genes in human CB HSC, CMP, GMP and MEP

ORGANISM(S): Homo sapiens  



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Identification of HIF2alpha as an important STAT5 target gene in human hematopoietic stem cells.

Fatrai Szabolcs S   Wierenga Albertus T J AT   Daenen Simon M G J SM   Vellenga Edo E   Schuringa Jan Jacob JJ  

Blood 20110124 12

The transcription factor signal transducer and activator of transcription 5 (STAT5) fulfills essential roles in self-renewal in mouse and human hematopoietic stem cells (HSCs), and its persistent activation contributes to leukemic transformation, although little molecular insight into the underlying mechanisms has been obtained. In the present study, we show that STAT5 can impose long-term expansion exclusively on human HSCs, not on progenitors. This was associated with an enhanced cobblestone f  ...[more]

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