Dataset Information


Homo sapiens

ABSTRACT: Transcriptome-wide changes in HeLa cell line investigated in response to Heat-shock stress

ORGANISM(S): Homo sapiens  



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Heat shock factor binding in Alu repeats expands its involvement in stress through an antisense mechanism.

Pandey Rajesh R   Mandal Amit K AK   Jha Vineet V   Mukerji Mitali M  

Genome Biology 20111123 11

Alu RNAs are present at elevated levels in stress conditions and, consequently, Alu repeats are increasingly being associated with the physiological stress response. Alu repeats are known to harbor transcription factor binding sites that modulate RNA pol II transcription and Alu RNAs act as transcriptional co-repressors through pol II binding in the promoter regions of heat shock responsive genes. An observation of a putative heat shock factor (HSF) binding site in Alu led us to explore whether,  ...[more]

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