Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Microarray analysis of total naïve and YFV-17D specific CD8 T cells in humans

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA136725 | ENA |

REPOSITORIES: ENA

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Publications


The differentiation of human memory CD8 T cells is not well understood. Here we address this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity in humans. We used in vivo deuterium labelling to mark CD8 T cells that proliferated in response to the virus and then assessed cellular turnover and longevity by quantifying deuterium dilution kinetics in YFV-specific CD8 T cells using mass spectrometry. This longitudinal analysis showed that the memory pool originat  ...[more]

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