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ABSTRACT: The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5 and Srf, Histone Modifications and MicroRNAs



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The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs.

Schlesinger Jenny J   Schueler Markus M   Grunert Marcel M   Fischer Jenny J JJ   Zhang Qin Q   Krueger Tammo T   Lange Martin M   Tönjes Martje M   Dunkel Ilona I   Sperling Silke R SR  

PLoS genetics 20110217 2

The transcriptome, as the pool of all transcribed elements in a given cell, is regulated by the interaction between different molecular levels, involving epigenetic, transcriptional, and post-transcriptional mechanisms. However, many previous studies investigated each of these levels individually, and little is known about their interdependency. We present a systems biology study integrating mRNA profiles with DNA-binding events of key cardiac transcription factors (Gata4, Mef2a, Nkx2.5, and Srf  ...[more]

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