Dataset Information


Drosophila melanogaster

ABSTRACT: The Yb Body, a Major Site for Piwi-associated RNA Biogenesis and a Gateway for Piwi Expression and Transport to the Nucleus in Somatic Cells

ORGANISM(S): Drosophila melanogaster  



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The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells.

Qi Hongying H   Watanabe Toshiaki T   Ku Hsueh-Yen HY   Liu Na N   Zhong Mei M   Lin Haifan H  

The Journal of biological chemistry 20101124 5

Despite exciting progress in understanding the Piwi-interacting RNA (piRNA) pathway in the germ line, less is known about this pathway in somatic cells. We showed previously that Piwi, a key component of the piRNA pathway in Drosophila, is regulated in somatic cells by Yb, a novel protein containing an RNA helicase-like motif and a Tudor-like domain. Yb is specifically expressed in gonadal somatic cells and regulates piwi in somatic niche cells to control germ line and somatic stem cell self-ren  ...[more]

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