Dataset Information


Homo sapiens

ABSTRACT: Interactions with Fibroblasts are Distinct in Basal-like and Luminal Breast Cancers

ORGANISM(S): Homo sapiens  



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Tumor intrinsic subtype is reflected in cancer-adjacent tissue.

Casbas-Hernandez Patricia P   Sun Xuezheng X   Roman-Perez Erick E   D'Arcy Monica M   Sandhu Rupninder R   Hishida Asahi A   McNaughton Kirk K KK   Yang Xiaohong R XR   Makowski Liza L   Sherman Mark E ME   Figueroa Jonine D JD   Troester Melissa A MA  

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20141202 2

<h4>Introduction</h4>Overall survival of early-stage breast cancer patients is similar for those who undergo breast-conserving therapy (BCT) and mastectomy; however, 10% to 15% of women undergoing BCT suffer ipsilateral breast tumor recurrence. The risk of recurrence may vary with breast cancer subtype. Understanding the gene expression of the cancer-adjacent tissue and the stromal response to specific tumor subtypes is important for developing clinical strategies to reduce recurrence risk.<h4>M  ...[more]

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