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ABSTRACT: Chromosome wide analysis of parental allele specific chromatin and DNA methylation in mouse



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Chromosome-wide analysis of parental allele-specific chromatin and DNA methylation.

Singh Purnima P   Wu Xiwei X   Lee Dong-Hoon DH   Li Arthur X AX   Rauch Tibor A TA   Pfeifer Gerd P GP   Mann Jeffrey R JR   Szabó Piroska E PE  

Molecular and cellular biology 20110214 8

To reveal the extent of domain-wide epigenetic features at imprinted gene clusters, we performed a high-resolution allele-specific chromatin analysis of over 100 megabases along the maternally or paternally duplicated distal chromosome 7 (Chr7) and Chr15 in mouse embryo fibroblasts (MEFs). We found that reciprocal allele-specific features are limited to imprinted genes and their differentially methylated regions (DMRs), whereas broad local enrichment of H3K27me3 (BLOC) is a domain-wide feature a  ...[more]

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