Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Correlation between maternal age and newborn DNA methylation

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA137185 | ENA |

REPOSITORIES: ENA

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Publications

Parental ages and levels of DNA methylation in the newborn are correlated.

Adkins Ronald M RM   Thomas Fridtjof F   Tylavsky Frances A FA   Krushkal Julia J  

BMC medical genetics 20110331


Changes in DNA methylation patterns with age frequently have been observed and implicated in the normal aging process and its associated increasing risk of disease, particularly cancer. Additionally, the offspring of older parents are at significantly increased risk of cancer, diabetes, and neurodevelopmental disorders. Only a proportion of these increased risks among the children of older parents can be attributed to nondisjunction and chromosomal rearrangements.Using a genome-wide survey of 27  ...[more]

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