Genomics

Dataset Information

59


ABSTRACT: A Bcl6-Smrt/Ncor repression program controls atherosclerosis

PROVIDER: PRJNA137601 | ENA |

REPOSITORIES: ENA

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Publications


Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macrophage-specific deletion of NCoR instead results in an anti-inflammatory phenotype along with robust systemic insulin sensitization in obese mice. We present evidence that derepression of LXRs contribut  ...[more]

Publication: 1/2

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