Dataset Information


Mus musculus

ABSTRACT: Expression data of reprogrammed miR-302/367-iPS cells

ORGANISM(S): Mus musculus  



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Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency.

Anokye-Danso Frederick F   Trivedi Chinmay M CM   Juhr Denise D   Gupta Mudit M   Cui Zheng Z   Tian Ying Y   Zhang Yuzhen Y   Yang Wenli W   Gruber Peter J PJ   Epstein Jonathan A JA   Morrisey Edward E EE  

Cell stem cell 20110401 4

Transcription factor-based cellular reprogramming has opened the way to converting somatic cells to a pluripotent state, but has faced limitations resulting from the requirement for transcription factors and the relative inefficiency of the process. We show here that expression of the miR302/367 cluster rapidly and efficiently reprograms mouse and human somatic cells to an iPSC state without a requirement for exogenous transcription factors. This miRNA-based reprogramming approach is two orders  ...[more]

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