Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: MiR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA138087 | ENA |

REPOSITORIES: ENA

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Publications


To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of malignant behaviors by regulating multiple targets. We performed a microRNA analysis of human melanoma, a highly invasive cancer, and found that miR-30b/30d upregulation correlates with stage, metastatic potential, shorter time to recurrence, and reduced overall survival. Ectopic expression of miR-30b/3  ...[more]

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