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Mus musculus

ABSTRACT: Expression data from BMDCs treated with BI2536 or vehicle control and stimulated with LPS or poly(I:C)

OTHER RELATED OMICS DATASETS IN: MSV000078507

PROVIDER: PRJNA138967 | ENA |

REPOSITORIES: ENA

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Expression data from BMDCs treated with BI2536 or vehicle control and stimulated with LPS or poly(I:C)

Project description:We used microarrays to detail the global programme of gene expression underlying Polo-like kinase inhibition with BI 2536 compound in mouse bone marrow-derived dendritic cells (BMDCs) stimulated with Toll-like receptor agonists LPS and poly(I:C). CD11c+ BMDCs were treated for 1 hour with BI 2536 (1µM) or vehicle control (DMSO) prior to stimulation with LPS or poly(I:C) for 4 h. Total RNA was extracted and prepared for hybridization on Affymetrix microarrays.

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Expression data from BMDCs treated with BI2536 or vehicle control and stimulated with LPS or poly(I:C)

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Mus musculus

Project description:Gene expression profiles of mice BMDCs treated with Nitidine Chloride or vehicle following LPS stimulation

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PDL2+, PDL2- and LPS treated PDL2- WT bone-marrow derived murine DCs

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Project description:With our experiments we have shown LP(Lactobacillus plantarum) mediated modification of immunogenic bone marrow derived dendritic cells (BMDCs) to acquire tolerogenic phenotype, to unravel the molecular mechanism of LP mediated immunomodulation we performed global transcriptomic Gut of old mice was reconstituted with LP, and RNA was extracted from LPS stimulated BMDCs from young, young treated with antibiotic cocktail, old and old-LP groups for gene array profiling by Agilent GeneChips.

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Next Generation Sequencing Facilitates Quantitative Analysis of Manganese (II) or LPS treated Wild Type BMDC Transcriptomes

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