Genomics

Dataset Information

0

Canis lupus familiaris


ABSTRACT: Madin-Darby Canine Kidney (MDCK) cells grown in 2-dimensional and 3-dimensional type I collagen culture.

ORGANISM(S): Canis lupus familiaris  

PROVIDER: PRJNA139089 | ENA |

REPOSITORIES: ENA

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Publications

Epithelial morphogenesis of MDCK cells in three-dimensional collagen culture is modulated by interleukin-8.

Wells Erika K EK   Yarborough OrLando O   Lifton Richard P RP   Cantley Lloyd G LG   Caplan Michael J MJ  

American journal of physiology. Cell physiology 20130313 10


Epithelial morphogenesis is dependent upon a variety of factors, many of which involve complex interactions between cells and their surrounding environments. We analyzed the patterns of differential gene expression associated with Madin-Darby canine kidney (MDCK) renal epithelial cells grown within a collagen gel in three-dimensional (3D) culture compared with those grown atop a collagen gel in two-dimensional (2D) culture. Under these conditions, MDCK cells spontaneously formed either hollow sp  ...[more]

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