Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Gene expression data following Cyclin T2 and Cyclin T1 depletion by shRNA in HeLa cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA139469 | ENA |

REPOSITORIES: ENA

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Publications

Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1.

Ramakrishnan Rajesh R   Yu Wendong W   Rice Andrew P AP  

BMC research notes 20110726


The elongation phase, like other steps of transcription by RNA Polymerase II, is subject to regulation. The positive transcription elongation factor b (P-TEFb) complex allows for the transition of mRNA synthesis to the productive elongation phase. P-TEFb contains Cdk9 (Cyclin-dependent kinase 9) as its catalytic subunit and is regulated by its Cyclin partners, Cyclin T1 and Cyclin T2. The HIV-1 Tat transactivator protein enhances viral gene expression by exclusively recruiting the Cdk9-Cyclin T1  ...[more]

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