Genomics,Multiomics

Dataset Information

0


ABSTRACT: Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Novel Role in Autophagy

OTHER RELATED OMICS DATASETS IN: E-GEOD-28082E-GEOD-28083E-GEOD-28084

PROVIDER: PRJNA139733 | ENA |

REPOSITORIES: ENA

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Publications

Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy.

Seo Young-Kyo YK   Jeon Tae-Il TI   Chong Hansook Kim HK   Biesinger Jacob J   Xie Xiaohui X   Osborne Timothy F TF  

Cell metabolism 20110401 4


Sterol regulatory element-binding proteins (SREBPs) are key transcriptional regulators of lipid metabolism. To define functional differences between the three mammalian SREBPs we used genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with different dietary conditions that enrich for specific SREBPs. We show that hepatic SREBP-2 binds preferentially to two different gene-proximal motifs. A Gene Ontology (GO) analysis suggests SREBP-2 target  ...[more]

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