Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Epigenome analysis of male identical twin pairs discordant for sexual orientation, age 21 to 55.

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA140523 | ENA |

REPOSITORIES: ENA

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Publications


From the moment of conception, we begin to age. A decay of cellular structures, gene regulation, and DNA sequence ages cells and organisms. DNA methylation patterns change with increasing age and contribute to age related disease. Here we identify 88 sites in or near 80 genes for which the degree of cytosine methylation is significantly correlated with age in saliva of 34 male identical twin pairs between 21 and 55 years of age. Furthermore, we validated sites in the promoters of three genes and  ...[more]

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