Dataset Information


Homo sapiens

ABSTRACT: Analysis of the human endothelial cell response to Borrelia burgdorferi wild-type and deleted in the gene encoding the integrin ligand P66 [experiment B]

ORGANISM(S): Homo sapiens  



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The Borrelia burgdorferi integrin ligand P66 affects gene expression by human cells in culture.

LaFrance Michelle E ME   Pierce Jessica V JV   Antonara Syliani S   Coburn Jenifer J  

Infection and immunity 20110516 8

Borrelia burgdorferi, an agent of Lyme disease, establishes persistent infection in immunocompetent animals and humans. Although the infection in humans can be cleared by antibiotic therapy, persistence in reservoir animals is necessary for the maintenance of the bacterium in the natural reservoir host⇔tick vector infectious cycle. B. burgdorferi binds to β(1)- and β(3)-chain integrins, and the P66 outer membrane protein is responsible for at least some of the integrin binding activity of the sp  ...[more]

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