Dataset Information


Mus musculus

ABSTRACT: IGH analysis in pro-B cells with H3K4me3, H3K4me2, H3K9ac, H3K27me3, Pax5 and CTCF [ChIP-Seq]

ORGANISM(S): Mus musculus  



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The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells.

Ebert Anja A   McManus Shane S   Tagoh Hiromi H   Medvedovic Jasna J   Salvagiotto Giorgia G   Novatchkova Maria M   Tamir Ido I   Sommer Andreas A   Jaritz Markus M   Busslinger Meinrad M  

Immunity 20110201 2

V(H)-DJ(H) recombination of the immunoglobulin heavy chain (Igh) locus is temporally and spatially controlled during early B cell development, and yet no regulatory elements other than the V(H) gene promoters have been identified throughout the entire V(H) gene cluster. Here, we discovered regulatory sequences that are interspersed in the distal V(H) gene region. These conserved repeat elements were characterized by the presence of Pax5 transcription factor-dependent active chromatin by binding  ...[more]

Publication: 1/2

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