Dataset Information


Mus musculus

ABSTRACT: Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells (mRNA)

ORGANISM(S): Mus musculus  



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Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.

Wu Hao H   D'Alessio Ana C AC   Ito Shinsuke S   Wang Zhibin Z   Cui Kairong K   Zhao Keji K   Sun Yi Eve YE   Zhang Yi Y  

Genes & development 20110401 7

Recent studies have demonstrated that the Ten-eleven translocation (Tet) family proteins can enzymatically convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). While 5mC has been studied extensively, little is known about the distribution and function of 5hmC. Here we present a genome-wide profile of 5hmC in mouse embryonic stem (ES) cells. A combined analysis of global 5hmC distribution and gene expression profile in wild-type and Tet1-depleted ES cells suggests that 5hmC is enrich  ...[more]

Publication: 1/2

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