Dataset Information


Homo sapiens

ABSTRACT: Sperm DNA methylation

ORGANISM(S): Homo sapiens  



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Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm.

Pacheco Sara E SE   Houseman E Andres EA   Christensen Brock C BC   Marsit Carmen J CJ   Kelsey Karl T KT   Sigman Mark M   Boekelheide Kim K  

PloS one 20110602 6

In previous studies using candidate gene approaches, low sperm count (oligospermia) has been associated with altered sperm mRNA content and DNA methylation in both imprinted and non-imprinted genes. We performed a genome-wide analysis of sperm DNA methylation and mRNA content to test for associations with sperm function.Sperm DNA and mRNA were isolated from 21 men with a range of semen parameters presenting to a tertiary male reproductive health clinic. DNA methylation was measured with the Illu  ...[more]

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