Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: PU.1 and C/EBPalpha synergistically program distinct response to NF-kappaB activation through establishing monocyte-specific enhancers (ChIP-chip data)

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA142033 | ENA |

REPOSITORIES: ENA

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Publications

PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers.

Jin Fulai F   Li Yan Y   Ren Bing B   Natarajan Rama R  

Proceedings of the National Academy of Sciences of the United States of America 20110314 13


Unraveling the complexity of transcriptional programs coded by different cell types has been one of the central goals of cell biology. By using genome-wide location analysis, we examined how two different cell types generate different responses to the NF-κB signaling pathway. We showed that, after TNF-α treatment, the NF-κB p65 subunit binds to distinct genome locations and subsequently induces different subsets of genes in human monocytic THP-1 cells versus HeLa cells. Interestingly, the differ  ...[more]

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