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Homo sapiens

ABSTRACT: Genome-wide analysis of gene expression in surgical specimens of primary glioblastoma multiform

OTHER RELATED OMICS DATASETS IN: GSE25632

PROVIDER: PRJNA142429 | ENA |

REPOSITORIES: ENA

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Homo sapiens

Project description:Genome-wide analysis of microRNA expression in surgical specimens of primary glioblastoma multiform

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Project description:We used a genome-wide coding gene expression profiling to identify a gene signature for the molecular classification or prognostic prediction of primary GBMs. Total RNA obtained from 21 surgical specimens of primary glioblastoma multiform.

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Project description:MicroRNA has a great potential in predicting survival of cancer patient. We used a genome-wide microRNA expression profiling to identify a miRNA signature for the prediction of clinical outcome of primary GBM patients. Total RNA obtained from 82 surgical specimens of primary glioblastoma multiform and 5 normal brain tissues from areas surrounding arteriovenous malformations (AVM) as control.

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Project description:Glioblastomas are lethal cancers defined by inevitable disease recurrence after maximal surgical and chemoradiological interventions. To identify possible dependencies in glioblastomas undetected by whole transcriptome sequencing, we examined the enhancer landscape marked by histone 3 lysine 27 acetylation (H3K27ac) in primary glioblastoma specimens through ChIP-seq.

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