Dataset Information


Homo sapiens

ABSTRACT: Effects of Evi1 knockdown and overexpression in SKOV-3 ovarian carcinoma cells

ORGANISM(S): Homo sapiens  



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Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors.

Bard-Chapeau Emilie A EA   Jeyakani Justin J   Kok Chung H CH   Muller Julius J   Chua Belinda Q BQ   Gunaratne Jayantha J   Batagov Arsen A   Jenjaroenpun Piroon P   Kuznetsov Vladimir A VA   Wei Chia-Lin CL   D'Andrea Richard J RJ   Bourque Guillaume G   Jenkins Nancy A NA   Copeland Neal G NG  

Proceedings of the National Academy of Sciences of the United States of America 20120119 6

Ecotropic viral integration site 1 (EVI1) is an oncogenic dual domain zinc finger transcription factor that plays an essential role in the regulation of hematopoietic stem cell renewal, and its overexpression in myeloid leukemia and epithelial cancers is associated with poor patient survival. Despite the discovery of EVI1 in 1988 and its emerging role as a dominant oncogene in various types of cancer, few EVI1 target genes are known. This lack of knowledge has precluded a clear understanding of  ...[more]

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