Project description:To compare the transcriptional networks governed by Sox2 in embryonic stem (ES) cells and trophoblast stem (TS) cells, we performed whole-genome expression analysis after tetracycline (Tet)-induced knockout of Sox2 in each cell type. A Tet-inducible Sox2 knockout ES cell line 2TS22C or its derivative TSC line 22CEROH2-TSC1 were treated with Tet for 4 days. A total of 12 samples from ES or TS cells cultured with or without Tet were analyzed in three biological replicates.

2013-10-17 | E-GEOD-28451 | biostudies-arrayexpress

Dynamics of Sox2 occupancy during the differentiation of embryonic stem cells into trophoblast stem cells.

Project description:To understand the mechanism underlying the versatility in transcriptional regulation by Sox2, we compared genome-wide binding sites of Sox2 in embryonic stem (ES) cells and trophoblast stem (TS) cells by chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq). A tetracycline-inducible Oct3/4 knockout ES cell line ZHBTc4 was treated with Tet for 4 days in the presence of FGF4 and mouse embryonic fibroblasts (MEFs).

2013-10-17 | E-GEOD-28453 | biostudies-arrayexpress

Sox2-regulatory networks in embryonic and trophoblast stem cells

Project description:Sox2-regulatory networks in embryonic and trophoblast stem cells

| PRJNA139231 | ENA

Mus musculus

Project description:ChIP-seq anlysis of Sox2, Tfap2c, and Cdx2 in trophoblast stem cells.

| PRJNA232935 | ENA

Mus musculus

Project description:Expression and ChIP-seq analyses of embryonic stem cells, extraembryonic endoderm stem cells, and trophoblast stem cells

| PRJNA115689 | ENA

Mus musculus

Project description:Dual knockdown of Esrrb and Sox2 in mouse embryonic stem cells

| PRJNA149721 | ENA

Mus musculus

Project description:Overexpression of trophoblast stem cell-enriched microRNAs promote trophoblast fate in embryonic stem cells.

| PRJNA316375 | ENA

Mus musculus

Project description:Dicer conditional knockout embryonic heart mutant vs control array

| PRJNA100449 | ENA

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