Dataset Information


Homo sapiens

ABSTRACT: Investigation of Isogenic Human Embryonic Stem Cells and Derived Induced Pluripotent Stem Cells and Differentiated Line

ORGANISM(S): Homo sapiens  



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Suppression of the imprinted gene NNAT and X-chromosome gene activation in isogenic human iPS cells.

Teichroeb Jonathan H JH   Betts Dean H DH   Vaziri Homayoun H  

PloS one 20111012 10

Genetic comparison between human embryonic stem cells and induced pluripotent stem cells has been hampered by genetic variation. To solve this problem, we have developed an isogenic system that allows direct comparison of induced pluripotent stem cells (hiPSCs) to their genetically matched human embryonic stem cells (hESCs). We show that hiPSCs have a highly similar transcriptome to hESCs. Global transcriptional profiling identified 102-154 genes (>2 fold) that showed a difference between isogen  ...[more]

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