Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Changes in miRNA expression in mouse primary visual cortex following visual deprivation

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA145495 | ENA |

REPOSITORIES: ENA

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Publications


Using quantitative analyses, we identified microRNAs (miRNAs) that were abundantly expressed in visual cortex and that responded to dark rearing and/or monocular deprivation. The most substantially altered miRNA, miR-132, was rapidly upregulated after eye opening and was delayed by dark rearing. In vivo inhibition of miR-132 in mice prevented ocular dominance plasticity in identified neurons following monocular deprivation and affected the maturation of dendritic spines, demonstrating its critic  ...[more]

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