Dataset Information


Mus musculus

ABSTRACT: Expression data from C/EBP alpha induced transdifferentiation of pre-B cells into macrophages

ORGANISM(S): Mus musculus  



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CCAAT/enhancer binding protein alpha (C/EBP(alpha))-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation.

Di Tullio Alessandro A   Vu Manh Thien Phong TP   Schubert Alexis A   Castellano Giancarlo G   Månsson Robert R   Graf Thomas T  

Proceedings of the National Academy of Sciences of the United States of America 20111003 41

Earlier work has shown that pre-B cells can be converted into macrophages by the transcription factor CCAAT/enhancer binding protein α at very high frequencies. Using this system, we performed a systematic analysis of whether during transdifferentiation the cells transiently reactivate progenitor-restricted genes or even retrodifferentiate. A transcriptome analysis of transdifferentiating cells showed that most genes are up- or down-regulated continuously, acquiring a macrophage phenotype within  ...[more]

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