Dataset Information


Mus musculus

ABSTRACT: A Wnt-Bmp feedback circuit controls inter-tissue signaling dynamics in tooth organogenesis

ORGANISM(S): Mus musculus  



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A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis.

O'Connell Daniel J DJ   Ho Joshua W K JW   Mammoto Tadanori T   Turbe-Doan Annick A   O'Connell Joyce T JT   Haseley Psalm S PS   Koo Samuel S   Kamiya Nobuhiro N   Ingber Donald E DE   Park Peter J PJ   Maas Richard L RL  

Science signaling 20120110 206

Many vertebrate organs form through the sequential and reciprocal exchange of signaling molecules between juxtaposed epithelial and mesenchymal tissues. We undertook a systems biology approach that combined the generation and analysis of large-scale spatiotemporal gene expression data with mouse genetic experiments to gain insight into the mechanisms that control epithelial-mesenchymal signaling interactions in the developing mouse molar tooth. We showed that the shift in instructive signaling p  ...[more]

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