Genomics

Dataset Information

59


ABSTRACT: A unique role of Cohesin-SA1 in gene regulation and development

PROVIDER: PRJNA147285 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

A unique role of cohesin-SA1 in gene regulation and development.

Remeseiro Silvia S   Cuadrado Ana A   Gómez-López Gonzalo G   Pisano David G DG   Losada Ana A  

The EMBO journal 20120313 9


Vertebrates have two cohesin complexes that consist of Smc1, Smc3, Rad21/Scc1 and either SA1 or SA2, but their functional specificity is unclear. Mouse embryos lacking SA1 show developmental delay and die before birth. Comparison of the genome-wide distribution of cohesin in wild-type and SA1-null cells reveals that SA1 is largely responsible for cohesin accumulation at promoters and at sites bound by the insulator protein CTCF. As a consequence, ablation of SA1 alters transcription of genes inv  ...[more]

Similar Datasets

2012-03-15 | E-GEOD-32320 | ArrayExpress
| PRJNA154891 | ENA
| PRJNA154497 | ENA
2012-03-15 | E-GEOD-32319 | ArrayExpress
2012-03-15 | E-GEOD-32234 | ArrayExpress
| GSE101921 | GEO
2015-04-07 | E-GEOD-59119 | ArrayExpress
2016-06-28 | E-GEOD-67783 | ArrayExpress
2014-10-21 | E-GEOD-62493 | ArrayExpress
2013-12-11 | E-GEOD-48938 | ArrayExpress