Genomics

Dataset Information

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Entamoeba histolytica


ABSTRACT: Transcriptional and functional analysis of trifluoromethionine resistance in Entamoeba histolytica

ORGANISM(S): Entamoeba histolytica  

PROVIDER: PRJNA147287 | ENA |

REPOSITORIES: ENA

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Publications

Transcriptional and functional analysis of trifluoromethionine resistance in Entamoeba histolytica.

Penuliar Gil M GM   Furukawa Atsushi A   Nakada-Tsukui Kumiko K   Husain Afzal A   Sato Dan D   Nozaki Tomoyoshi T  

Journal of Antimicrobial Chemotherapy 20111122 2


OBJECTIVES: Drug resistance in parasitic protozoa is an obstacle to successful chemotherapy. Understanding how pathogens respond to drugs is crucial in preventing resistance. Previously, we have shown that in Entamoeba histolytica, methionine γ-lyase (EhMGL) downregulation results in trifluoromethionine resistance. The transcriptional response, however, of this parasite to the drug is not known. In this study, we used microarray analysis to determine whether additional genes are involved. METHOD  ...[more]

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