Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Gene expression in synovial membranes from patients with early and end-stage osteoarthritis

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA147293 | ENA |

REPOSITORIES: ENA

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Publications


Osteoarthritis, characterized by the breakdown of articular cartilage in synovial joints, has long been viewed as the result of 'wear and tear'. Although low-grade inflammation is detected in osteoarthritis, its role is unclear. Here we identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of co  ...[more]

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