Dataset Information


Homo sapiens

ABSTRACT: The role of miR-199 in HIF1a-mediated hypoxia response in epithelial ovarian cancer cells

ORGANISM(S): Homo sapiens  



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Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis.

Joshi Hemant P HP   Subramanian Indira V IV   Schnettler Erica K EK   Ghosh Goutam G   Rupaimoole Rajesha R   Evans Colleen C   Saluja Manju M   Jing Yawu Y   Cristina Ivan I   Roy Sabita S   Zeng Yan Y   Shah Vijay H VH   Sood Anil K AK   Ramakrishnan Sundaram S  

Proceedings of the National Academy of Sciences of the United States of America 20140324 14

Hypoxia-driven changes in the tumor microenvironment facilitate cancer metastasis. In the present study, we investigated the regulatory cross talk between endocytic pathway, hypoxia, and tumor metastasis. Dynamin 2 (DNM2), a GTPase, is a critical mediator of endocytosis. Hypoxia decreased the levels of DNM2. DNM2 promoter has multiple hypoxia-inducible factor (HIF)-binding sites and genetic deletion of them relieved hypoxia-induced transcriptional suppression. Interestingly, DNM2 reciprocally re  ...[more]

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