Dataset Information


Mus musculus

ABSTRACT: Harnessing of the Nucleosome Remodeling Deacetylase complex controls lymphocyte development and prevents leukemogenesis

ORGANISM(S): Mus musculus  



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Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis.

Zhang Jiangwen J   Jackson Audrey F AF   Naito Taku T   Dose Marei M   Seavitt John J   Liu Feifei F   Heller Elizabeth J EJ   Kashiwagi Mariko M   Yoshida Toshimi T   Gounari Fotini F   Petrie Howard T HT   Georgopoulos Katia K  

Nature immunology 20111113 1

Cell fate depends on the interplay between chromatin regulators and transcription factors. Here we show that activity of the Mi-2β nucleosome-remodeling and histone-deacetylase (NuRD) complex was controlled by the Ikaros family of lymphoid lineage-determining proteins. Ikaros, an integral component of the NuRD complex in lymphocytes, tethered this complex to active genes encoding molecules involved in lymphoid differentiation. Loss of Ikaros DNA-binding activity caused a local increase in chroma  ...[more]

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