Dataset Information


Mus musculus

ABSTRACT: Sustained axon regeneration induced by a synergy of PTEN and SOCS3 deletion

ORGANISM(S): Mus musculus  



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Sustained axon regeneration induced by co-deletion of PTEN and SOCS3.

Sun Fang F   Park Kevin K KK   Belin Stephane S   Wang Dongqing D   Lu Tao T   Chen Gang G   Zhang Kang K   Yeung Cecil C   Feng Guoping G   Yankner Bruce A BA   He Zhigang Z  

Nature 20111106 7377

A formidable challenge in neural repair in the adult central nervous system (CNS) is the long distances that regenerating axons often need to travel in order to reconnect with their targets. Thus, a sustained capacity for axon regeneration is critical for achieving functional restoration. Although deletion of either phosphatase and tensin homologue (PTEN), a negative regulator of mammalian target of rapamycin (mTOR), or suppressor of cytokine signalling 3 (SOCS3), a negative regulator of Janus k  ...[more]

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