Genomics

Dataset Information

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ABSTRACT: Prognostic DNA Methylation Patterns in CN-AML; a genome wide methylation and gene expression study

PROVIDER: PRJNA147349 | ENA |

REPOSITORIES: ENA

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Cytogenetically normal acute myeloid leukemia (CN-AML) compose between 40% and 50% of all adult acute myeloid leukemia (AML) cases. In this clinically diverse group, molecular aberrations, such as FLT3-ITD, NPM1, and CEBPA mutations, recently have added to the prognostic accuracy. Aberrant DNA methylation is a hallmark of cancer, including AML. We investigated in total 118 CN-AML samples in a test and a validation cohort for genome-wide promoter DNA methylation with Illumina Methylation Bead arr  ...[more]

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