Genomics

Dataset Information

118


ABSTRACT: Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes.

PROVIDER: PRJNA147463 | ENA |

REPOSITORIES: ENA

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Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes.

Wong Piu P   Hattangadi Shilpa M SM   Cheng Albert W AW   Frampton Garrett M GM   Young Richard A RA   Lodish Harvey F HF  

Blood 20110822 16


It is unclear how epigenetic changes regulate the induction of erythroid-specific genes during terminal erythropoiesis. Here we use global mRNA sequencing (mRNA-seq) and chromatin immunoprecipitation coupled to high-throughput sequencing (CHIP-seq) to investigate the changes that occur in mRNA levels, RNA polymerase II (Pol II) occupancy, and multiple posttranslational histone modifications when erythroid progenitors differentiate into late erythroblasts. Among genes induced during this developm  ...[more]

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