Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA147477 | ENA |

REPOSITORIES: ENA

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Publications

Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism.

Waight Jeremy D JD   Hu Qiang Q   Miller Austin A   Liu Song S   Abrams Scott I SI  

PloS one 20111116 11


Myeloid-derived suppressor cells (MDSC) are induced under diverse pathologic conditions, including neoplasia, and suppress innate and adaptive immunity. While the mechanisms by which MDSC mediate immunosuppression are well-characterized, details on how they develop remain less understood. This is complicated further by the fact that MDSC comprise multiple myeloid cell types, namely monocytes and granulocytes, reflecting diverse stages of differentiation and the proportion of these subpopulations  ...[more]

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