Dataset Information


Plasmodium falciparum

ABSTRACT: Whole transcriptome analysis identifies a subset of Group A var genes that encode the malaria parasite ligands for binding to human brain endothelial cells

ORGANISM(S): Plasmodium falciparum  



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A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells.

Claessens Antoine A   Adams Yvonne Y   Ghumra Ashfaq A   Lindergard Gabriella G   Buchan Caitlin C CC   Andisi Cheryl C   Bull Peter C PC   Mok Sachel S   Gupta Archna P AP   Wang Christian W CW   Turner Louise L   Arman Mònica M   Raza Ahmed A   Bozdech Zbynek Z   Rowe J Alexandra JA  

Proceedings of the National Academy of Sciences of the United States of America 20120522 26

Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum. The pathology of cerebral malaria is characterized by the accumulation of infected erythrocytes (IEs) in the microvasculature of the brain caused by parasite adhesins on the surface of IEs binding to human receptors on microvascular endothelial cells. The parasite and host molecules involved in this interaction are unknown. We selected three P. falciparum strains (HB3, 3D7, and IT/FCR3) for binding to a hu  ...[more]

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