Genomics

Dataset Information

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Gallus gallus


ABSTRACT: Gene expression analysis of chickens (Gallus gallus) infected with recombinant influenza viruses

ORGANISM(S): Gallus gallus  

PROVIDER: PRJNA147955 | ENA |

REPOSITORIES: ENA

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Publications

Identification of host genes linked with the survivability of chickens infected with recombinant viruses possessing H5N1 surface antigens from a highly pathogenic avian influenza virus.

Uchida Yuko Y   Watanabe Chiaki C   Takemae Nobuhiro N   Hayashi Tsuyoshi T   Oka Takehiko T   Ito Toshihiro T   Saito Takehiko T  

Journal of virology 20111221 5


Seventeen recombinant viruses were generated by a reverse genetic technique to elucidate the pathogenicity of highly pathogenic avian influenza viruses (HPAIVs) in chickens. The recombinant viruses generated possessed hemagglutinin (HA) and neuraminidase (NA) genes from an HPAIV. Other segments were combinations of the genes from an HPAIV and two low-pathogenic avian influenza viruses (LPAIVs) derived from chicken (LP) and wild bird (WB). Exchange of whole internal genes from an HPAIV with those  ...[more]

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