Genomics

Dataset Information

0

Mus musculus


ABSTRACT: A functional map of DNA-associated proteolysis

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA148047 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR387766.fastq.gz Fastqsanger.gz
SRR387767.fastq.gz Fastqsanger.gz
SRR387768.fastq.gz Fastqsanger.gz
SRR387769.fastq.gz Fastqsanger.gz
SRR387775.fastq.gz Fastqsanger.gz
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Publications

Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation.

Catic André A   Suh Carol Y CY   Hill Cedric T CT   Daheron Laurence L   Henkel Theresa T   Orford Keith W KW   Dombkowski David M DM   Liu Tao T   Liu X Shirley XS   Scadden David T DT  

Cell 20131201 6


Transcription factor activity and turnover are functionally linked, but the global patterns by which DNA-bound regulators are eliminated remain poorly understood. We established an assay to define the chromosomal location of DNA-associated proteins that are slated for degradation by the ubiquitin-proteasome system. The genome-wide map described here ties proteolysis in mammalian cells to active enhancers and to promoters of specific gene families. Nuclear-encoded mitochondrial genes in particula  ...[more]

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