Dataset Information


Saccharomyces cerevisiae

ABSTRACT: Global analysis of mRNA decay intermediates in Saccharomyces cerevisiae

ORGANISM(S): Saccharomyces cerevisiae  



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Global analysis of mRNA decay intermediates in Saccharomyces cerevisiae.

Harigaya Yuriko Y   Parker Roy R  

Proceedings of the National Academy of Sciences of the United States of America 20120629 29

The general pathways of eukaryotic mRNA decay occur via deadenylation followed by 3' to 5' degradation or decapping, although some endonuclease sites have been identified in metazoan mRNAs. To determine the role of endonucleases in mRNA degradation in Saccharomyces cerevisiae, we mapped 5' monophosphate ends on mRNAs in wild-type and dcp2 xrn1 yeast cells, wherein mRNA endonuclease cleavage products are stabilized. This led to three important observations. First, only few mRNAs that undergo low-  ...[more]

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