Dataset Information


Homo sapiens

ABSTRACT: Gene Expression differences in Hepatic Parenchyma and Portal Tracts in Hepatitis C Virus Infected Subjects with High and Low Fibrosis

ORGANISM(S): Homo sapiens  



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Laser captured hepatocytes show association of butyrylcholinesterase gene loss and fibrosis progression in hepatitis C-infected drug users.

Munshaw Supriya S   Hwang Hyon S HS   Torbenson Michael M   Quinn Jeffrey J   Hansen Kasper D KD   Astemborski Jacquie J   Mehta Shruti H SH   Ray Stuart C SC   Thomas David L DL   Balagopal Ashwin A  

Hepatology (Baltimore, Md.) 20120706 2

Chronic hepatitis C virus (HCV) infection is complicated by hepatic fibrosis. Hypothesizing that early fibrogenic signals may originate in cells susceptible to HCV infection, hepatocyte gene expression was analyzed from persons with chronic HCV at different stages of liver fibrosis. Four HCV-infected subjects with precirrhosis liver fibrosis (Ishak fibrosis 3-5) were matched for age, race, and gender to five HCV-infected subjects with no evidence of fibrosis (Ishak fibrosis 0). Hepatocytes from  ...[more]

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