Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Comparison of gene expression alterations induced by distinct PI3K inhibitors

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA148663 | ENA |

REPOSITORIES: ENA

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Publications


The pan-phosphoinositide 3-kinase (PI3K) inhibitor BKM120 was found, at high concentrations, to cause cell death in various cellular systems, irrespective of their level of PI3K addiction. Transcriptional and biochemical profiling studies were used to identify the origin of these unexpected and apparently PI3K-independent effects. At 5- to 10-fold, the concentration needed to half-maximally inhibit PI3K signaling. BKM120 treatment caused changes in expression of mitotic genes and the induction o  ...[more]

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