Dataset Information


Homo sapiens

ABSTRACT: Expression data from docetaxel-resistant prostate cancer cell lines

ORGANISM(S): Homo sapiens  



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Identification of docetaxel resistance genes in castration-resistant prostate cancer.

Marín-Aguilera Mercedes M   Codony-Servat Jordi J   Kalko Susana G SG   Fernández Pedro L PL   Bermudo Raquel R   Buxo Elvira E   Ribal María José MJ   Gascón Pedro P   Mellado Begoña B  

Molecular cancer therapeutics 20111025 2

Docetaxel-based chemotherapy is the standard first-line therapy in metastatic castration-resistant prostate cancer (CRPC). However, most patients eventually develop resistance to this treatment. In this study, we aimed to identify key molecular genes and networks associated with docetaxel resistance in two models of docetaxel-resistant CRPC cell lines and to test for the most differentially expressed genes in tumor samples from patients with CRPC. DU-145 and PC-3 cells were converted to docetaxe  ...[more]

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