Dataset Information


Mus musculus

ABSTRACT: Comparison of mouse epithelial tumor initiating cells to mesenchymal tumor initiating cells generated by EMT

ORGANISM(S): Mus musculus  



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ROCK1 inhibition promotes the self-renewal of a novel mouse mammary cancer stem cell.

Castro David J DJ   Maurer Jochen J   Hebbard Lionel L   Oshima Robert G RG  

Stem cells (Dayton, Ohio) 20130101 1

The differentiation of stem-like tumor cells may contribute to the cellular heterogeneity of breast cancers. We report the propagation of highly enriched mouse mammary cancer stem cells that retain the potential to differentiate both in vivo and in culture and their use to identify chemical compounds that influence both self-renewal and differentiation. We identify epithelial tumor-initiating cells (ETICs) that express lineage markers of both basal and luminal mammary cell lineages and retain th  ...[more]

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